Château Doisy-Védrines is a wine estate based in the commune of Barsac (part of the Sauternes appellation) known for its sweet, white botrytized dessert wines. The estate was rated a Second Growth in the 1855 classification of Sauternes and Barsac and produces a sweet white wine from the Sémillon, Sauvignon Blanc and Muscadelle grown on the estate.

The 35-hectare vineyard was originally part of a wider Doisy holding established in the area in 1704. In the years following the French revolution, the estate began to fracture, divided into Château Doisy-Védrines, Château Doisy-Daëne and Château Doisy-Dubroca.
Doisy-Védrines is the largest of the three, although former Doisy-Daëne proprietor, Denis Dubourdieu acquired the Doisy-Dubroca estate in its entirety in 2014 and has consolidated the two.

Doisy-Védrines has been owned by the Castéja family since the 19th Century. The Castéjas – a well-known name in the region – also own several other Bordeaux estates through their major négociant business Borie-Manoux. These include Château Batailly in Pauillac and Château Trotte Vieille in Saint-Émilion. The vineyard is planted to 80 percent Sémillon, 15 percent Sauvignon Blanc and five percent Muscadelle. As is often the case in local sweet wine production, the grapes are harvested in successive waves, or "tries" in French. Pickers will only harvest the most botrytis-affected bunches, leaving others for subsequent "tries".